Dorsal raphe and circuit architecture
Current work tests how the serotonergic dorsal raphe and its downstream circuits may compute futility and modulate the transition to passivity. We combine connectomics from a whole-brain electron-microscopy dataset with whole-brain imaging, pharmacology, and optogenetic perturbations to investigate how this dorsal raphe population communicates with the norepinephrine–astroglia circuit described by Mu et al. (2019) and the habenula–raphe circuit described by Andalman et al. (2019), and whether these pathways are connected.